TNC Featured Speakers

TNC Virtual Event Featured Speakers
Sunday, 28 June, 2020 


Wolfgang Grisold, MD, PhD, FAAN Ludwig Boltzmann Institute for Experimental und Clinical Traumatology, Vienna, Austria 
Title:  Toxic Neuropathies 

 

Toxic Neuropathies Toxic neuropathies have several causes and the classification goes far beyond the axonal and demyelinating type. In addition to the commonly considered targets for toxicity as the dorsal root ganglia, nerve and axons, also receptors , nerve ending and small fibers need to be considered. Also Ion channels and ionophores are sites of toxicity. The onset of toxicity can be acute, is usually delayed, but can also result in late effects, and is rarely also self propagating. The frequency of toxic neuropathy is not known, and in addition to commonly used industrial agents, heavy metals, drugs , recreational substances, also rare and nutritional neuropathies occur.

 


 

     

 



TNC Featured Speakers
Monday, 29 June, 2020 


Francesca Bartoini, PhD, Columbia University, New York, NY, USA 
Title:  Pathogenic Role of Tubulin Post Translational Modifications in Axon Degeneration

        

Tubulin, its post-translational modifications, microtubule dynamics and stability play critical roles in neurons, including regulation of long-distance transport, microtubule severing, Ca2+ homeostasis and mitochondria energetics. Each of these functions provides a potential mechanism underlying axon degeneration. Herein, we report that in sensory neurons the CIPN inducing drug bortezomib causes axonopathy and disrupted mitochondria motility by increasing delta 2 tubulin, the only irreversible tubulin modification and marker of hyperstable microtubules. Our data provide a new paradigm for the risk associated with enhanced tubulin longevity in the onset of peripheral neuropathy and offer the unexplored potential for targeting the enzymes involved in this tubulin modification in drug therapies aimed at preventing axonal injury observed in CIPN and possibly other types of related neuropathies.


 

     

 

 

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