IDNC Featured Speakers

IDNC Featured Speakers
Sunday, 28 June, 2020


David Bennett, PhD University of Oxford, Oxford, UK
TitlePathomechanisms of Neuropathic Pain

   

I will discuss the latest understanding of the pathomechanisms of neuropathic pain with particular emphasis on painful neuropathies and channelopathies. This will include emerging data on inherited and acquired pain channelopathies as well as more common conditions such as painful diabetic neuropathy. I will explain current understanding in how rare variants in ion channels can confer risk of neuropathic pain. I will conclude by explaining how such information can inform treatment choices.


Robert Sorge, PhD University of Alabama at Birmingham, Birmingham, AL, USA 
Title: An Improved Preclinical Model of Type 2 Diabetes in Mice 

Type 2 diabetes (T2D) affects millions of Americans each year and the myriad of T2D-related symptoms significantly reduces quality of life. Preclinical models of T2D have focused on high-fat diets (HFD) despite treatment directed at reducing carbohydrates. Our Standard American Diet (SAD) is modeled on an American diet with high processed carbohydrates and sugar. Previous studies have shown that our SAD leads to increased immune cell activation in the brain and spinal cord and prolonged recovery from injury in both mice and rats. Here, in a direct head-to-head comparison of our SAD and a standard HFD, both diets resulted in obesity, but only the SAD-fed animals showed glucose intolerance, bladder changes, prolonged recovery from injury and impaired retinal function. Our data suggest that a high-carbohydrate diet (SAD) may be a more translatable model of T2D.

 

IDNC Featured Speakers
Monday, 29 June, 2020

Theodore Price, PhD University of Texas at Dallas, Richardson, TX, USA
Title
Using RNA Sequencing on Human Peripheral Nerves to Understand Mechanisms Driving Painful Neuropathies

   

I The focus of this talk will be molecular mechanisms that cause painful neuropathies. While great mechanistic insight has come from animal models, RNA sequencing is revolutionizing how we can obtain molecular detail from clinical samples. My talk will focus on how we can use this data to gain mechanistic insight into how sexually dimorphic mechanisms drive painful neuropathies. Implications for therapeutics will be an emphasis of the presentation.will discuss as series of studies in which my colloborators and I adopted a multi-disciplinary approach to explore novel clinical, molecular, and brain imaging findings that differentiate patients with painful and painless diabetic neuropathy.



Catharina Faber, MD, PhD Maastricht University Medical Centre, Maastricht, Netherlands 
Title: 
Sodium Channelopathies in Painful Small Fiber and in Painful Diabetic Peripheral Neuropathy

The presentation will discuss the current insights on the role of sodium channelopathies in painful small fiber and painful diabetic neuropathy.

Catharina Faber is a full Professor in Neuromuscular Disorders at the Maastricht University Medical Centre in the Netherlands. She has extensive experience in painful/small fibre neuropathies, is head of the skin-biopsy lab in Maastricht, and co-responsible for painful/small fibre neuropathy on-going randomized trials. She authored and co-authored over 150 peer-reviewed papers including reviews and book chapters. Research in the past five years focused on genetic causes of small fibre neuropathy, more specifically on sodium channelopathies. The research extended to the role of sodium channels in small fiber neuropathy (collaboration with prof. Waxman and prof. Lauria). A collaborative project, ‘Probing the role of sodium channels in painful neuropathies (PROPANE Study)’, was granted by the EU (Health.2013.2.2.1-5; Understanding and controlling pain. FP7-Health-2013-Innovation-1), and focuses on the genetic mechanisms underlying neuropathic pain, identifying molecular targets which may reveal new druggable sites, creating the possibility for personalized pain medicine.

 

 

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