IDNC Featured Speakers

IDNC Featured Speakers
Sunday, 28 June, 2020


David Bennett, PhD University of Oxford, Oxford, UK
TitlePathomechanisms of Neuropathic Pain

   

I will discuss the latest understanding of the pathomechanisms of neuropathic pain with particular emphasis on painful neuropathies and channelopathies. This will include emerging data on inherited and acquired pain channelopathies as well as more common conditions such as painful diabetic neuropathy. I will explain current understanding in how rare variants in ion channels can confer risk of neuropathic pain. I will conclude by explaining how such information can inform treatment choices.


 

   

 

IDNC Featured Speakers
Monday, 29 June, 2020

Theodore Price, PhD University of Texas at Dallas, Richardson, Texas
Title
Using RNA Sequencing on Human Peripheral Nerves to Understand Mechanisms Driving Painful Neuropathies

   

I The focus of this talk will be molecular mechanisms that cause painful neuropathies. While great mechanistic insight has come from animal models, RNA sequencing is revolutionizing how we can obtain molecular detail from clinical samples. My talk will focus on how we can use this data to gain mechanistic insight into how sexually dimorphic mechanisms drive painful neuropathies. Implications for therapeutics will be an emphasis of the presentation.will discuss as series of studies in which my colloborators and I adopted a multi-disciplinary approach to explore novel clinical, molecular, and brain imaging findings that differentiate patients with painful and painless diabetic neuropathy.


Catharina Faber, MD, PhD Maastricht University Medical Centre, Maastricht, Netherlands 
Title: 
Sodium Channelopathies in Painful Small Fiber and in Painful Diabetic Peripheral Neuropathy

The presentation will discuss the current insights on the role of sodium channelopathies in painful small fiber and painful diabetic neuropathy.

Catharina Faber is a full Professor in Neuromuscular Disorders at the Maastricht University Medical Centre in the Netherlands. She has extensive experience in painful/small fibre neuropathies, is head of the skin-biopsy lab in Maastricht, and co-responsible for painful/small fibre neuropathy on-going randomized trials. She authored and co-authored over 150 peer-reviewed papers including reviews and book chapters. Research in the past five years focused on genetic causes of small fibre neuropathy, more specifically on sodium channelopathies. The research extended to the role of sodium channels in small fiber neuropathy (collaboration with prof. Waxman and prof. Lauria). A collaborative project, ‘Probing the role of sodium channels in painful neuropathies (PROPANE Study)’, was granted by the EU (Health.2013.2.2.1-5; Understanding and controlling pain. FP7-Health-2013-Innovation-1), and focuses on the genetic mechanisms underlying neuropathic pain, identifying molecular targets which may reveal new druggable sites, creating the possibility for personalized pain medicine.

 

 

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